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Sofosbuvir has been invented to fight chronic hepatitis C and to be used as a peroral combination anti-virus therapy. The medicine can be successfully administered to HIV-coinfected patients with cirrhosis. In certain cases Sofosbuvir may be prescribed for the medical treatment of patients who can’t be treated with Interferon for any reason. Sofosbuvir, therefore, is currently one of the most promising medicines created for the treatment of hepatitis C. Its efficacy and safety has been evaluated and proved by six clinical studies involving circa 2 thousand of patients. The use of sofosbuvir + ledipasvir as part of combination therapy instead of Interferon which is known to cause certain adverse effects will significantly improve the quality of life in patients suffering from hepatitis C.