Description
Details
Uses
Lenalid (Lenalidomide) is a medication used to treat patients with a low red blood cell count, and who are anemic, caused by myelodysplastic syndrome. It is also used with a combination of drugs to treat multiple myeloma.
For adults with MM, the recommended dose of lenalidomide is 25 mg orally once daily at the same time each day, with or without food, on days 1–21 of repeated 28-day cycles in combination with oral dexamethasone (40 mg once daily on days 1, 8, 15, and 22 of each 28-day cycle). The starting dose of dexamethasone may be decreased (20 mg orally once daily on days 1, 8, 15, and 22) in patients older than 75 years of age. Continue lenalidomide and dexamethasone combination therapy until disease progression or the occurrence of unacceptable or toxic adverse effects in patients who are not eligible.
In multiple myeloma patients, those patients with mild renal impairment had an AUC 56% greater than those with normal renal function.
Patients with Hepatic Disease: The pharmacokinetics of lenalidomide in patients with hepatic impairment have not been studied.
Age: The effects of age on the pharmacokinetics of lenalidomide have not been studied.
Pediatric: No pharmacokinetic data are available in patients below the age of 18 years.
Gender: The effects of gender on the pharmacokinetics of lenalidomide have not been studied.
Race: Pharmacokinetic differences due to race have not been studied.
As noted earlier, the starting dose of lenalidomide should be adjusted in patients with renal impairment and in patients requiring dialysis and may require adjustment based on clinical or laboratory findings. Lenalidomide capsules are swallowed whole with water and should not be opened, crushed, or chewed.
As with all medications, Lenalid (Lenalidomide) has the potential to cause side effects in some patients. Common side effects include headaches, vomiting, nausea, trouble sleeping coughing, dizziness, back pain, a dry mouth or skin, tiredness, loss or increased appetite, sweating or night sweats, and weakness. If these symptoms get worse or do not go away, contact your physician.
Rare side effects include severe unexplained weakness or tiredness, chills, bleeding or bruising, fever, stomach pains, muscle or joint pain, unusual shortness of breath, numbness, chest pain, and an allergic reaction. If you experience any of these symptoms, contact your physician immediately or seek emergency medical treatment.
Before taking Lenalid (Lenalidomide) you must tell your physician if you are receiving dialysis, have a tumor, cancer, or kidney problems.
It is extremely important that women do not become pregnant while taking this drug as it can cause birth defects in unborn children. It can also be passed on through sexual intercourse with a man who is taking the medication. Make sure to always use precautions when having sexual intercourse with pregnant women when taking this drug.
Lenalid 10mg Capsule is highly Insecure to use during pregnancy. Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
Lenalid 10mg Capsule is probably Insecure to use during lactation. Limited human data suggest that the medicine could represent a significant risk to the baby.
Lenalid 10mg Capsule should be used with attention in patients with kidney disease. Dose adjustment of Lenalid 10mg Capsule may be require. Please consult your doctor.
