Description
Details
Uses
Acute leukemia, beta thalassaemia, chronic myeloid leukaemia, myeloproliferative disorders, sickle cell anaemia, solid tumor.
How it works
Hydroxycarbamide causes inhibition of DNA synthesis during the S-phase of cell division by acting as a ribonucleotide reductase inhibitor resulting to cell death. It is S-phase specific.
Common side effects
erythema, alopecia, hallucination, hyperuricemia, nausea and vomiting, anorexia, chills, disorientation, drowsiness, elevated hepatic enzymes, impaired renal tubular function, dysuria, rashes, Fever, constipation, diarrhea, convulsions., dizziness, stomatitis, increased creatinine, malaise, increased blood urea nitrogen
