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Cenforce (Generic Viagra) 200mg Zoom

Cenforce (Generic Viagra) 200mg

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International Brand: Generic Viagra
Active Ingredients: Sildenafil Citrate
Medicine Name: Cenforce 200
Company Name: Centurion lab
Strength: 200mg
Pack Size: Pack of 30 Tablets
Delivery Time: 8 - 15 Days

Availability: In stock

$35.70 (30 tablets)




Qty Per Pack / Per Pill Total Price You Save
2 packs
(60 tablets)
$32.15 / 1.07 $64.3 USD $7.14
3 packs
(90 tablets)
$28.57 / 0.95 $85.7 USD $21.42
4 packs
(120 tablets)
$25 / 0.83 $100 USD $42.84
6 packs
(180 tablets)
$21.42 / 0.71 $128.5 USD $85.68
8 packs
(240 tablets)
$17.14 / 0.57 $137.1 USD $148.51
10+ packs
(300 tablets)
$14.28 / 0.48 $142.8 USD $214.2
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$35.70 (30 tablets)
Description

    Details

    Mechanism of Action

    The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.

    Cenforce 200 enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Cenforce 200 at recommended doses has no effect in the absence of sexual stimulation.

    Binding Characteristics

    Studies in vitro have shown that Cenforce 200 is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). Sildenafil is approximately 4,000-fold more selective for PDE5 compared to PDE3. PDE3 is involved in control of cardiac contractility. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision [see Clinical Pharmacology (12.2)].

    In addition to human corpus cavernosum smooth muscle, PDE5 is also found in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle, brain, heart, liver, kidney, lung, pancreas, prostate, bladder, testis, and seminal vesicle. The inhibition of PDE5 in some of these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of NO observed

    in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.

    Pharmacodynamics

    Effects of VIAGRA on Erectile Response:

    In eight double-blind, placebo-controlled crossover studies of patients with either organic or psychogenic erectile dysfunction, sexual stimulation resulted in improved erections, as assessed by an objective measurement of hardness and duration of erections (RigiScan®), after VIAGRA administration compared with placebo. Most studies assessed the efficacy of VIAGRA approximately 60 minutes post dose. The erectile response, as assessed by RigiScan®, generally increased with increasing sildenafil dose and plasma concentration. The time course of effect was examined in one study, showing an effect for up to 4 hours but the response was diminished compared to 2 hours.

    Effects of Cenforce 200 on Blood Pressure:

    Single oral doses of Cenforce 200 administered to healthy volunteers produced decreases in sitting blood pressure (mean maximum decrease in systolic/diastolic blood pressure of 8.3/5.3 mmHg). The decrease in sitting blood pressure was most notable approximately 1-2 hours after dosing, and was not different than placebo at 8 hours. Similar effects on blood pressure were noted with 25 mg, 50 mg and 100 mg of Cenforce 200, therefore the effects are not related to dose or plasma levels within this dosage range. Larger effects were recorded among patients receiving concomitant nitrates

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